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KMID : 1189420050180030001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2005 Volume.18 No. 3 p.1 ~ p.17
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Effects of Sochungyong-tang on Cytokine Gene Expression in Mouse Alveolar Macrophage
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Park In-Gi
Sim Sung-Yong
Byun Hak-Sung
Kim Kyung-Jun
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Abstract
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In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis of lung disease. This Experiment was conducted to investigate the effects of Sochungyong-tang on gene expressions in Mouse Alveolar Macrophage. Fer this purpose, we observed the cytokines (, IL-6, IL-10, iNOS, ). We picked the alveolar macrophage out of mice and cultured it. We analyzed the cytokine gene expression by reverse transcription-PCR.
The results obtained were as follows:
1 . Sochungyong-tang showed inhibitory effects on in time and concentration. 2. Sochungyong-tang showed inhibitory effects on IL-6 in time and concentration. 3. Sochungyong-tang showed inhibitory effects on IL-10 in concentration. 4. Sochungyong-tang showed inhibitory effects on iNOS. 5. Sochungyong-tang showed inhibitory effects on in time and concentration. 6. Sochungyong-tang showed on inhibitory effects on MIP-1a,MIP-1B,MIP-1r,TCF-B,TNF-a . According to above results, it is supposed that Sochungyong-tang has the inhibitory effects on cytokine gene expression in mouse alveolar macrophage and can be usefully applied for curing inflammatory process of lung disease. Advanced studies are required to investigate the cure mechanism of Sochungyong-tang in the future.
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KEYWORD
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Sochungyongtang, Cytokine, GeneExpression, AlveolarMacrophage
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